منابع مشابه
Chemotherapy for brain tumors.
Traditionally, cytotoxic drugs have played a limited role in the treatment of brain tumors, but important advances in chemotherapy have occurred during the past decade. Certain central nervous system (CNS) malignancies are remarkably chemosensitive. These include primary CNS lymphoma, medulloblastoma, oligodendroglioma, and intracranial germ-cell tumors. This review focuses on advances in the c...
متن کاملChemotherapy for Brain Tumors
悪性腫瘍 に対す る化学療 法の原則 には3通 りの仮定が あ る.第1は 治癒 するためにはすべての腫瘍 細胞が死滅 し,除 去 され なければな らない とす る説,第2は 生体 に は免疫学 的防御機構 が存 在す るか ら,あ る数 まで腫瘍 細 胞 を減 らす ことができれ ば,あ とは生体 の 自然 に備わ っ た防衛能 力で治癒 す ることができる とす る説,そ して第 3は,悪 性腫瘍 細胞を分化す ることがで きれば,た とえ 腫瘍 細胞が存 在 していて も増殖,転 移 によって生体 に悪 影響 を及ぼす ことな く,正 常組織 と平和共存で きるであ ろ うとする仮説 である.残 念 なが ら今 目,こ の仮説のい ずれが正 しいのか,そ の詳細は不明であ る.現 実的 には 悪性腫瘍 細胞 を減 らすためには5種 類 の治療 方 式 が あ る.す なわち,...
متن کاملImmunotherapy for Pediatric Brain Tumors
Malignant brain tumors are the most common cause of solid cancer death in children. New targeted therapies are vital to improve treatment outcomes, but must be developed to enable trafficking across the blood brain barrier (BBB). Since activated T cells cross the BBB, cancer immunotherapy can be harnessed to unlock the cytotoxic potential of the immune system. However, standard of care treatmen...
متن کاملPediatric Brain Tumors
Primitive neuroectodermal tumors (PNET) of the brain include medulloblastoma (MB) and central nervous system primitive neuroectodermal tumor (CNS PNET) subtypes, which share histological features yet differ at the genomic level and in clinical outcome. Delineation of the genetic anomalies between PNET subtypes is a current challenge for establishing effective targeted therapeutic strategies aga...
متن کاملChemotherapy for malignant brain tumors of childhood.
During the past 3 decades, chemotherapeutic agents for the treatment of pediatric brain tumors have been extensively evaluated in a myriad of schedules, doses, and combinations. Remarkable advances in outcome have been achieved for certain children, notably those with medulloblastoma, but with a high cost to quality of life. In addition, the success achieved for medulloblastoma is offset by lac...
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ژورنال
عنوان ژورنال: Japanese Journal of Neurosurgery
سال: 2003
ISSN: 0917-950X,2187-3100
DOI: 10.7887/jcns.12.405